MTDH

Across TCGA patient cohorts, MTDH RNA expression is significantly associated with the protein abundance of many other proteins, with 10,372 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MTDH-associated proteins across cancer lineages are YTHDF3, STK3, and YWHAZ. Each is linked with MTDH in more than 6 cancer types. Because this analysis shows association rather than direction, both MTDH-to-partner and partner-to-MTDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTDH versus YTHDF3 in OV, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MTDH→partner) and Y-score (partner→MTDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	YTHDF3 →	+0.285	+0.691	<.001	<.001	3	7
BRCA	STK3 →	+0.444	+0.751	<.001	<.001	3	7
OV	YWHAZ →	+0.387	+0.616	<.001	<.001	3	6
OV	POP1 →	+0.264	+0.681	.002	<.001	3	6
OV	MTDH_S308 →	+0.671	+0.548	<.001	<.001	3	6
OV	OTUD6B →	+0.539	+0.776	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,372 associations by consensus.

MTDH vs YTHDF3 — OV

Explore this scatter interactively →