MTDH

Across TCGA patient cohorts, MTDH protein abundance is significantly associated with the RNA expression of many other genes, with 14,205 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MTDH-associated genes across cancer lineages are MTURN, ZNF706, and KIDINS220. Each is linked with MTDH in more than 5 cancer types. Because this analysis shows association rather than direction, both MTDH-to-partner and partner-to-MTDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTDH versus MTURN in BRCA, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTDH→partner) and Y-score (partner→MTDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTURN →	-0.850	-0.374	<.001	<.001	3	6
OV	ZNF706 →	+0.758	+0.583	<.001	<.001	3	5
OV	KIDINS220 →	-0.599	-0.359	.004	.006	3	5
BRCA	NIPSNAP3B →	-0.783	-0.363	<.001	.001	3	5
OV	MTR →	-0.844	-0.458	.001	<.001	3	5
GBM	THRA →	-0.705	-0.164	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,205 associations by consensus.

MTDH vs MTURN — BRCA

Explore this scatter interactively →