MTDH

Across TCGA patient cohorts, MTDH mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTDH-associated genes across cancer lineages are Akt_pT308, PRAS40_pT246, and Caspase-7-cleavedD198. Each is linked with MTDH in more than 2 cancer types. Because this analysis shows association rather than direction, both MTDH-to-partner and partner-to-MTDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by MTDH-low versus MTDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTDH→partner) and Y-score (partner→MTDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.518	+2.115	.025	.016	3	3
UCEC	PRAS40_pT246 →	+0.170	+1.515	.007	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.682	+3.019	.001	<.001	3	2
UCEC	14-3-3_beta →	-0.129	-3.780	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.340	-2.247	<.001	.001	3	1
UCEC	eIF4E →	+0.166	+1.847	.032	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Akt_pT308 by MTDH expression — UCEC

Explore this box plot interactively →