MTDH

Across TCGA cell cohorts, MTDH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,989 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTDH-associated GO terms across cancer lineages are Blastocyst growth, Positive regulation of mitotic cell cycle, and DNA damage tolerance. Each is linked with MTDH in more than 11 cancer types. Because this analysis shows association rather than direction, both MTDH-to-partner and partner-to-MTDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blastocyst growth grouped by MTDH-low versus MTDH-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTDH→partner) and Y-score (partner→MTDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Blastocyst growth →	+0.175	+1.122	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cell cycle →	+0.092	+1.410	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA damage tolerance →	+0.065	+0.894	<.001	<.001	3	11
BREAST	Positive regulation of mitotic cell cycle phase transition →	+0.089	+0.871	.002	.001	2	12
STOMACH	Phosphatidylinositol metabolic process →	+0.061	+0.949	.003	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of t-circle formation →	-0.182	-1.105	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,989 associations by consensus.

Blastocyst growth by MTDH expression — OVARY

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