MTDH

Across TCGA cell cohorts, MTDH mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTDH-associated genes across cancer lineages are TRIM42, CEACAM4, and TCP10L2. Each is linked with MTDH in more than 1 cancer types. Because this analysis shows association rather than direction, both MTDH-to-partner and partner-to-MTDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM42 grouped by MTDH-low versus MTDH-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTDH→partner) and Y-score (partner→MTDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRIM42 →	+0.019	+4.169	<.001	.001	3	2
BLOOD_Lymphoma	CEACAM4 →	+0.042	+3.927	<.001	.004	3	2
SKIN	TCP10L2 →	+0.139	+5.415	<.001	.004	3	1
SKIN	PRR30 →	+0.013	+6.022	<.001	.001	3	1
LARGE_INTESTINE	PRSS54 →	+0.035	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR10A4 →	+0.048	+3.938	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TRIM42 by MTDH expression — LUNG_SCLC

Explore this box plot interactively →