Across TCGA pan-cancer cohorts, MTCYBP16 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MTCYBP16’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MTCYBP16 RNA is repressed in tumor relative to normal tissue. In most cancer types MTCYBP16 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC, COAD, and KICH are the cancer types where MTCYBP16 tumor–normal differential expression is most reproducible.