MTCO3P21

Across TCGA pan-cancer cohorts, MTCO3P21 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MTCO3P21’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MTCO3P21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTCO3P21 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

KIRC, UCEC, and ESCA are the cancer types where MTCO3P21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTCO3P21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.058	<.001	8	view →
UCEC	All	All	−0.127	.019	4	view →
ESCA	All	II,III,IV	+0.125	.037	2	view →
PRAD	All	All	+0.018	.043	2	view →
LIHC	All	All	+0.020	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MTCO3P21–KIRC

Open the KIRC breakdown →