MTCO1P53

Across TCGA pan-cancer cohorts, MTCO1P53 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MTCO1P53’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where MTCO1P53 RNA is repressed in tumor relative to normal tissue. In most cancer types MTCO1P53 is over-expressed in tumor, although a few such as PAAD and KIRC show the opposite, repressed pattern.

PAAD, KICH, and KIRC are the cancer types where MTCO1P53 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTCO1P53 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PAAD	Female	All	−1.320	.031	4	view →
KICH	Female	All	+0.967	.002	2	view →
KIRC	Female	All	−0.357	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MTCO1P53–PAAD

Open the PAAD breakdown →