MTCO1P46

Across TCGA pan-cancer cohorts, MTCO1P46 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MTCO1P46’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MTCO1P46 RNA is repressed in tumor relative to normal tissue. In most cancer types MTCO1P46 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and PAAD are the cancer types where MTCO1P46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTCO1P46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.037	.001	6	view →
HNSC	All	All	−0.010	.010	5	view →
PAAD	Female	All	−0.090	.012	2	view →
KICH	Female	II,III,IV	+0.051	.003	2	view →
STAD	All	II,III,IV	−0.027	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MTCO1P46–KIRC

Open the KIRC breakdown →