MTCO1P40

Across TCGA pan-cancer cohorts, MTCO1P40 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MTCO1P40’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MTCO1P40 RNA is repressed in tumor relative to normal tissue. In most cancer types MTCO1P40 is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

HNSC, LUSC, and KIRP are the cancer types where MTCO1P40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTCO1P40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.986	<.001	10	view →
LUSC	All	All	−0.465	.001	4	view →
KIRP	Female	II,III,IV	−1.611	.046	3	view →
KIRC	Female	All	−0.680	.001	3	view →
PAAD	Female	All	−1.575	.040	2	view →
KICH	Female	All	+1.252	.002	2	view →
CHOL	Male	All	−0.926	.016	2	view →
COAD	All	All	−0.901	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MTCO1P40–HNSC

Open the HNSC breakdown →