MTCL1

Across TCGA pan-cancer cohorts, MTCL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MTCL1 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MTCL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTCL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, LUAD, and GBM are the cancer types where MTCL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.870	0.664	.007	20	view →
LUAD	OS	Tertile	II,III,IV	0.472	0.861	.007	11	view →
GBM	OS	Tertile	All	0.618	0.421	.031	4	view →
PDAC	OS	Median	IV	0.836	0.491	.024	4	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.787	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MTCL1–HNSC (DFS)

Open the HNSC breakdown →