MTCH2

Across TCGA patient cohorts, MTCH2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTCH2-associated genes across cancer lineages are c-Met_pY1235, MSH2, and Caspase-8. Each is linked with MTCH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTCH2-to-partner and partner-to-MTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by MTCH2-low versus MTCH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCH2→partner) and Y-score (partner→MTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.096	+2.817	.018	.036	3	1
UCEC	MSH2 →	-0.412	-2.990	.001	.036	2	1
UCEC	Caspase-8 →	-0.338	-3.169	.014	.019	2	1
UCEC	c-Kit →	-0.260	-3.169	.042	.020	2	1
UCEC	p62 Lck ligand →	+0.390	+3.169	.029	.020	1	1
UCEC	PCNA →	+0.328	+3.169	.005	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

c-Met_pY1235 by MTCH2 expression — UCEC

Explore this box plot interactively →