MTCH2

Across TCGA cell cohorts, MTCH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,542 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTCH2-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid segregation, Pyruvate decarboxylation to acetyl-CoA, and Regulation of cell cycle checkpoint. Each is linked with MTCH2 in more than 12 cancer types. Because this analysis shows association rather than direction, both MTCH2-to-partner and partner-to-MTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid segregation grouped by MTCH2-low versus MTCH2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCH2→partner) and Y-score (partner→MTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic sister chromatid segregation →	+0.157	+1.090	<.001	.001	3	13
LUNG_SCLC	Pyruvate decarboxylation to acetyl-CoA →	+0.167	+0.562	<.001	<.001	3	13
SOFT_TISSUE	Regulation of cell cycle checkpoint →	+0.086	+0.473	.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic metaphase/anaphase transition →	+0.134	+0.918	.003	<.001	3	12
STOMACH	Negative regulation of chromosome segregation →	+0.126	+0.545	.002	.006	2	13
BLOOD_Myeloma	DNA replication initiation →	+0.149	+0.679	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,542 associations by consensus.

Regulation of mitotic sister chromatid segregation by MTCH2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →