MTCH1

Across TCGA pan-cancer cohorts, MTCH1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MTCH1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MTCH1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTCH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, LUAD, and COAD are the cancer types where MTCH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.864	0.561	.009	28	view →
LUAD	DFS	Tertile	III,IV	0.527	0.977	.009	20	view →
COAD	DFS	Tertile	All	1.000	0.920	.034	12	view →
PDAC	DFS	Median	All	0.327	0.472	.013	7	view →
GBM	DFS	Tertile	All	0.472	0.283	.035	4	view →
UCEC	DFS	Tertile	All	0.783	0.945	.044	4	view →
CCRCC	DFS	Median	II,III,IV	0.611	0.844	.026	3	view →
LSCC	DFS	Tertile	II,III,IV	0.810	0.504	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MTCH1–HNSC (DFS)

Open the HNSC breakdown →