MTCH1

Across TCGA patient cohorts, MTCH1 mutation is significantly associated with the RNA expression of many other genes, with 507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTCH1-associated genes across cancer lineages are KLF17P2, RNU6-1036P, and CCL5. Each is linked with MTCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTCH1-to-partner and partner-to-MTCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF17P2 grouped by MTCH1-low versus MTCH1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCH1→partner) and Y-score (partner→MTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KLF17P2 →	+0.104	+7.954	<.001	.008	3	2
BRCA	RNU6-1036P →	+0.352	+7.731	<.001	.009	3	2
UCEC	CCL5 →	+1.715	+2.343	<.001	.003	3	1
UCEC	RNA5SP414 →	+0.476	+2.255	<.001	.004	3	1
UCEC	IGHV2-70 →	+1.583	+2.321	.002	.006	3	1
UCEC	CCL4 →	+1.183	+2.343	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 507 associations by consensus.

KLF17P2 by MTCH1 expression — HNSC

Explore this box plot interactively →