MTCH1

Across TCGA patient cohorts, MTCH1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTCH1-associated genes across cancer lineages are STAT3_pY705, IGFBP2, and p62 Lck ligand. Each is linked with MTCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTCH1-to-partner and partner-to-MTCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by MTCH1-low versus MTCH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCH1→partner) and Y-score (partner→MTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.260	-3.169	.023	.018	3	2
UCEC	IGFBP2 →	-1.070	-3.321	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.461	+3.469	.001	.002	3	1
UCEC	PCNA →	+0.258	+2.999	.006	.035	3	1
UCEC	Annexin-1 →	+0.568	+3.189	.013	.010	3	1
UCEC	Src_pY527 →	-0.475	-2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

STAT3_pY705 by MTCH1 expression — UCEC

Explore this box plot interactively →