MTBP

Across TCGA cell cohorts, MTBP mutation is significantly associated with the RNA expression of many other genes, with 174 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTBP-associated genes across cancer lineages are MTRNR2L10, MTRNR2L6, and TFAP2D. Each is linked with MTBP in more than 1 cancer types. Because this analysis shows association rather than direction, both MTBP-to-partner and partner-to-MTBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L10 grouped by MTBP-low versus MTBP-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTBP→partner) and Y-score (partner→MTBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MTRNR2L10 →	+0.012	+5.169	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
CNS	IFNG →	+0.043	+5.321	.003	.005	3	1
CNS	PTH2 →	+0.120	+5.321	<.001	.005	3	1
CNS	ASB10 →	+0.062	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 174 associations by consensus.

MTRNR2L10 by MTBP expression — BREAST

Explore this box plot interactively →