MTARC2

Across TCGA patient cohorts, MTARC2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTARC2-associated genes across cancer lineages are ATM, mTOR, and CD49b. Each is linked with MTARC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTARC2-to-partner and partner-to-MTARC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MTARC2-low versus MTARC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTARC2→partner) and Y-score (partner→MTARC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.488	-2.459	.026	.020	3	2
UCEC	mTOR →	-0.174	-2.999	.026	.035	3	1
UCEC	CD49b →	-0.351	-2.986	.010	.035	3	1
UCEC	Notch1 →	+0.196	+2.459	.003	.020	1	2
UCEC	p62 Lck ligand →	+0.416	+2.331	.008	.019	2	1
UCEC	Caspase-7-cleavedD198 →	+0.962	+2.459	<.001	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ATM by MTARC2 expression — UCEC

Explore this box plot interactively →