Across TCGA patient cohorts, MTARC1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTARC1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Bak, and c-Met_pY1235. Each is linked with MTARC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTARC1-to-partner and partner-to-MTARC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTARC1→partner) and Y-score (partner→MTARC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.734	+3.000	.020	.036	3	2
UCEC	Bak →	+0.325	+2.321	.009	.035	3	2
UCEC	c-Met_pY1235 →	+0.083	+2.321	.026	.035	3	2
SKCM	IRS1 →	+0.287	+3.000	.001	.036	3	1
SKCM	AMPK_alpha →	+0.215	+3.000	.007	.036	3	1
UCEC	Caspase-8 →	-0.273	-3.169	.030	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

MTARC1 survival (RNA) · tumor vs normal (RNA) · all MTARC1 data types