Across TCGA cell cohorts, MTARC1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTARC1-associated genes across cancer lineages are DEFA4, NPY2R, and SIGLEC5. Each is linked with MTARC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTARC1-to-partner and partner-to-MTARC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTARC1→partner) and Y-score (partner→MTARC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	NPY2R →	+0.005	+4.217	<.001	.001	3	1
LUNG_SCLC	SIGLEC5 →	+0.042	+3.232	.002	.008	3	1
LUNG_SCLC	TMIGD3 →	+0.411	+3.232	.001	.008	3	1
LUNG_SCLC	DNMT3L →	+0.615	+3.502	.002	.007	3	1
BLOOD_Leukemia	HRG →	+0.343	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

MTARC1 survival (RNA) · tumor vs normal (RNA) · all MTARC1 data types