MTAPP2

Across TCGA pan-cancer cohorts, MTAPP2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MTAPP2 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MTAPP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MTAPP2 expression acts as an unfavorable survival marker, although some lineages such as CESC and KICH show a favorable association.

UVM, THCA, and LUSC are the cancer types where MTAPP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.231	0.824	<.001	81	view →
THCA	OS	Tertile	III,IV	0.581	0.826	.001	54	view →
LUSC	DFS	Tertile	III,IV	0.495	0.731	.010	47	view →
OV	OS	Median	All	0.638	0.739	.007	36	view →
LGG	DFS	Tertile	All	0.752	0.858	<.001	27	view →
ACC	DFS	Median	IV	0.193	0.468	.033	24	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
CESC	DFS	Quartile	II,III,IV	0.896	0.732	.033	16	view →
KICH	DFS	Median	All	1.000	0.716	.015	16	view →
THYM	DFS	Tertile	III,IV	1.000	0.501	.018	14	view →
LUAD	OS	Median	II,III,IV	0.657	0.792	.037	14	view →
UCEC	DFS	Tertile	All	0.577	0.652	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MTAPP2–UVM (OS)

Open the UVM breakdown →