Across TCGA patient cohorts, MTAP RNA expression is significantly associated with the go_rna of many other GO terms, with 7,166 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible MTAP-associated GO terms across cancer lineages are L-methionine salvage from methylthioadenosine, Amino acid salvage, and Prenylation. Each is linked with MTAP in more than 32 cancer types. Because this analysis shows association rather than direction, both MTAP-to-partner and partner-to-MTAP results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTAP→partner) and Y-score (partner→MTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	L-methionine salvage from methylthioadenosine →	+0.124	+1.014	<.001	<.001	3	33
SCLC	Amino acid salvage →	+0.196	+0.734	<.001	.004	3	31
SCLC	Prenylation →	+0.132	+1.313	<.001	<.001	3	31
SCLC	Methionine biosynthetic process →	+0.120	+0.953	<.001	<.001	1	32
SCLC	Centrosome duplication →	+0.119	+1.009	<.001	<.001	3	30
CHOL	5S class rRNA transcription by RNA polymerase III →	+0.093	+0.973	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

Exploration

MTAP survival (RNA) · tumor vs normal (RNA) · all MTAP data types