MTAP

Across TCGA patient cohorts, MTAP mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTAP-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4G. Each is linked with MTAP in more than 1 cancer types. Because this analysis shows association rather than direction, both MTAP-to-partner and partner-to-MTAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MTAP-low versus MTAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTAP→partner) and Y-score (partner→MTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.247	-2.169	.008	.003	3	1
UCEC	EGFR →	-0.182	-1.765	.002	.014	3	1
UCEC	eIF4G →	+0.282	+3.169	.015	.018	3	1
UCEC	ACC1 →	+0.292	+2.335	.032	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.463	+1.765	.015	.014	3	1
UCEC	INPP4B →	-0.257	-1.874	.034	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

EGFR_pY1068 by MTAP expression — UCEC

Explore this box plot interactively →