MTAP

Across TCGA cell cohorts, MTAP RNA expression is significantly associated with the go_rna of many other GO terms, with 2,608 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTAP-associated GO terms across cancer lineages are Negative regulation of immature T cell proliferation, Negative regulation of immature T cell proliferation in thymus, and Positive regulation of macrophage apoptotic process. Each is linked with MTAP in more than 10 cancer types. Because this analysis shows association rather than direction, both MTAP-to-partner and partner-to-MTAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of immature T cell proliferation grouped by MTAP-low versus MTAP-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTAP→partner) and Y-score (partner→MTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of immature T cell proliferation →	+1.341	+3.816	<.001	<.001	3	11
URINARY_TRACT	Negative regulation of immature T cell proliferation in thymus →	+1.182	+3.514	<.001	<.001	3	10
URINARY_TRACT	Positive regulation of macrophage apoptotic process →	+1.072	+2.514	<.001	.007	3	8
SOFT_TISSUE	Centriole replication →	+0.100	+1.214	<.001	.004	3	7
LUNG_NSCLC_LUAD	Negative regulation of B cell proliferation →	+0.161	+2.120	<.001	<.001	3	7
URINARY_TRACT	Regulation of immature T cell proliferation →	+0.252	+3.885	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,608 associations by consensus.

Negative regulation of immature T cell proliferation by MTAP expression — URINARY_TRACT

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