MTA2

Across TCGA patient cohorts, MTA2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTA2-associated genes across cancer lineages are PDCD4, eEF2, and ERK2. Each is linked with MTA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MTA2-to-partner and partner-to-MTA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MTA2-low versus MTA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTA2→partner) and Y-score (partner→MTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.776	-3.312	<.001	.010	2	4
UCEC	eEF2 →	+0.431	+2.000	.007	.032	3	2
UCEC	ERK2 →	+0.233	+1.874	.007	.049	3	2
UCEC	ETS-1 →	+0.292	+3.169	.041	.019	3	2
UCEC	GAPDH →	+0.632	+3.169	.008	.019	2	2
UCEC	GSK-3_pS9 →	-0.430	-2.999	.018	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PDCD4 by MTA2 expression — UCEC

Explore this box plot interactively →