MTA2

Across TCGA cell cohorts, MTA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,126 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTA2-associated GO terms across cancer lineages are Positive regulation of attachment of mitotic spindle microtubules to kinetochore, DNA strand elongation involved in DNA replication, and mRNA alternative polyadenylation. Each is linked with MTA2 in more than 16 cancer types. Because this analysis shows association rather than direction, both MTA2-to-partner and partner-to-MTA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of attachment of mitotic spindle microtubules to kinetochore grouped by MTA2-low versus MTA2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTA2→partner) and Y-score (partner→MTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.211	+0.809	.005	.001	3	17
BONE	DNA strand elongation involved in DNA replication →	+0.161	+0.683	.004	.001	3	17
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.096	+0.735	<.001	<.001	3	16
BLOOD_Myeloma	DNA-templated DNA replication →	+0.124	+0.984	.001	<.001	3	16
SOFT_TISSUE	Regulation of DNA repair →	+0.065	+0.643	.001	.004	3	16
SOFT_TISSUE	Regulation of double-strand break repair →	+0.071	+0.655	<.001	.005	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,126 associations by consensus.

Positive regulation of attachment of mitotic spindle microtubules to kinetochore by MTA2 expression — BONE

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