MTA2

Across TCGA cell cohorts, MTA2 mutation is significantly associated with the RNA expression of many other genes, with 623 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTA2-associated genes across cancer lineages are IL21, MS4A13, and OR4C12. Each is linked with MTA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTA2-to-partner and partner-to-MTA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by MTA2-low versus MTA2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTA2→partner) and Y-score (partner→MTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IL21 →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4M2 →	+0.267	+4.887	<.001	.009	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	SMR3B →	+0.034	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 623 associations by consensus.

IL21 by MTA2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →