Across TCGA patient cohorts, MTA1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTA1-associated genes across cancer lineages are PI3K-p85, p62 Lck ligand, and PDCD4. Each is linked with MTA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTA1-to-partner and partner-to-MTA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTA1→partner) and Y-score (partner→MTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	+0.187	+1.765	.017	.014	3	2
UCEC	p62 Lck ligand →	+0.349	+3.459	.004	.005	3	2
UCEC	PDCD4 →	-0.458	-1.765	.009	.014	3	2
UCEC	4E-BP1 →	+0.311	+2.252	.002	.005	3	2
COAD	eIF4E →	+0.293	+3.012	<.001	.018	2	2
COAD	PREX1 →	+0.274	+3.195	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

MTA1 survival (RNA) · tumor vs normal (RNA) · all MTA1 data types