Across TCGA cell cohorts, MTA1 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTA1-associated genes across cancer lineages are IQCF5, APOA4, and FTHL17. Each is linked with MTA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTA1-to-partner and partner-to-MTA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTA1→partner) and Y-score (partner→MTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.079	+4.201	<.001	.001	3	2
LUNG_NSCLC_LUAD	APOA4 →	+0.023	+4.215	.005	.002	3	1
LUNG_NSCLC_LUAD	FTHL17 →	+2.174	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	COX6A2 →	+1.269	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	MS4A10 →	+0.505	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.025	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

MTA1 survival (RNA) · tumor vs normal (RNA) · all MTA1 data types