MT2A

Across TCGA patient cohorts, MT2A protein abundance is significantly associated with the RNA expression of many other genes, with 13,251 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MT2A-associated genes across cancer lineages are SIRPA, MT1E, and MT1X. Each is linked with MT2A in more than 7 cancer types. Because this analysis shows association rather than direction, both MT2A-to-partner and partner-to-MT2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MT2A versus SIRPA in LUAD, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT2A→partner) and Y-score (partner→MT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SIRPA →	+0.711	+1.356	<.001	<.001	3	7
COAD	MT1E →	+1.940	+1.551	.007	.005	1	8
GBM	MT1X →	+1.436	+0.765	<.001	.001	3	6
UCEC	CHST11 →	+0.932	+1.187	<.001	<.001	3	6
LUAD	SLC2A3 →	+0.911	+0.998	.003	.002	3	6
OV	PDCD1LG2 →	+0.853	+1.523	.007	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,251 associations by consensus.

MT2A vs SIRPA — LUAD

Explore this scatter interactively →