MT2A

Across TCGA cell cohorts, MT2A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,636 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MT2A-associated GO terms across cancer lineages are Cellular response to zinc ion, Detoxification of copper ion, and Stress response to copper ion. Each is linked with MT2A in more than 18 cancer types. Because this analysis shows association rather than direction, both MT2A-to-partner and partner-to-MT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to zinc ion grouped by MT2A-low versus MT2A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MT2A→partner) and Y-score (partner→MT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to zinc ion →	+0.305	+4.274	<.001	<.001	3	19
LIVER	Detoxification of copper ion →	+0.547	+4.616	<.001	<.001	3	18
LIVER	Stress response to copper ion →	+0.547	+4.616	<.001	<.001	3	18
SOFT_TISSUE	Response to copper ion →	+0.210	+3.811	<.001	<.001	3	18
LIVER	Stress response to metal ion →	+0.341	+4.255	<.001	<.001	3	18
LIVER	Detoxification of inorganic compound →	+0.266	+4.157	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,636 associations by consensus.

Cellular response to zinc ion by MT2A expression — BONE

Explore this box plot interactively →