MT1XP1

Across TCGA pan-cancer cohorts, MT1XP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MT1XP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MT1XP1 RNA is repressed in tumor relative to normal tissue. In most cancer types MT1XP1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and THCA are the cancer types where MT1XP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT1XP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−1.647	<.001	11	view →
KICH	All	III,IV	−1.839	<.001	10	view →
THCA	Male	All	−1.654	<.001	10	view →
LIHC	Female	II,III,IV	−3.170	<.001	9	view →
UCEC	All	All	+1.245	<.001	6	view →
BRCA	Female	All	−0.831	<.001	6	view →
KIRC	Male	All	−0.652	<.001	6	view →
HNSC	All	II,III,IV	−0.459	.006	6	view →
LUAD	All	All	−0.428	.003	6	view →
READ	All	All	−1.036	.008	4	view →
CHOL	Male	All	−2.338	<.001	3	view →
STAD	All	III,IV	−1.183	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MT1XP1–KIRP

Open the KIRP breakdown →