Across TCGA patient cohorts, MT1X mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT1X-associated genes across cancer lineages are RNU6-822P, RNU6-66P, and RNU6-618P. Each is linked with MT1X in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1X-to-partner and partner-to-MT1X results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1X→partner) and Y-score (partner→MT1X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-822P →	+0.455	+4.621	<.001	.008	3	1
UCEC	RNU6-66P →	+0.569	+5.335	<.001	.003	3	1
UCEC	RNU6-618P →	+0.706	+4.969	<.001	.002	3	1
UCEC	SNORA70J →	+0.599	+5.474	<.001	<.001	3	1
UCEC	SNORD116-8 →	+0.921	+4.499	<.001	.005	3	1
UCEC	RNU6-306P →	+0.703	+4.903	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

MT1X survival (RNA) · tumor vs normal (RNA) · all MT1X data types