Across TCGA patient cohorts, MT1M mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT1M-associated genes across cancer lineages are Notch1, Tuberin, and Bak. Each is linked with MT1M in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1M-to-partner and partner-to-MT1M results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1M→partner) and Y-score (partner→MT1M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.182	+2.331	.003	.019	3	2
UCEC	Tuberin →	+0.385	+2.594	.001	.006	3	2
UCEC	Bak →	+0.338	+2.807	.001	.003	3	2
UCEC	C-Raf →	+0.204	+3.321	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.255	-2.459	.020	.018	3	1
UCEC	EGFR_pY1173 →	+0.080	+2.142	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

MT1M survival (RNA) · tumor vs normal (RNA) · all MT1M data types