MT1HL1

Across TCGA pan-cancer cohorts, MT1HL1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated MT1HL1 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MT1HL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MT1HL1 expression acts as an unfavorable survival marker.

HNSC, BLCA, and LUSC are the cancer types where MT1HL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.130	0.751	<.001	48	view →
BLCA	OS	Median	All	0.074	0.720	<.001	48	view →
LUSC	DFS	Median	All	0.079	0.758	<.001	36	view →
UCEC	OS	Median	All	0.599	0.876	.001	18	view →
STAD	DFS	Median	All	0.149	0.710	<.001	15	view →
LGG	OS	Median	All	0.194	0.830	<.001	8	view →
COAD	OS	Median	All	0.259	0.806	.028	6	view →
LUAD	OS	Median	All	0.176	0.670	.039	3	view →
KICH	DFS	Median	All	0.425	0.847	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MT1HL1–HNSC (OS)

Open the HNSC breakdown →