Across TCGA patient cohorts, MT1H mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT1H-associated genes across cancer lineages are SNORD115-45, F8A2, and ZNF736P3Y. Each is linked with MT1H in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1H-to-partner and partner-to-MT1H results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1H→partner) and Y-score (partner→MT1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD115-45 →	+0.689	+5.186	<.001	.007	3	2
UCEC	F8A2 →	+0.074	+5.694	<.001	.003	3	1
LUAD	ZNF736P3Y →	+0.049	+7.930	<.001	.008	3	1
UCEC	OR6C70 →	+0.075	+5.551	.008	.004	3	1
UCEC	RNU7-29P →	+0.778	+6.722	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

MT1H survival (RNA) · tumor vs normal (RNA) · all MT1H data types