MT1G

Across TCGA pan-cancer cohorts, MT1G mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MT1G data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MT1G mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MT1G expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where MT1G mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.361	0.845	<.001	39	view →
HNSC	DFS	Median	All	1.000	0.905	.009	23	view →
CCRCC	DFS	Tertile	All	0.618	1.000	.026	5	view →
UCEC	DFS	Quartile	All	0.812	0.981	.010	2	view →
GBM	OS	Tertile	All	0.318	0.637	.034	2	view →
LSCC	DFS	Median	All	0.937	0.608	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MT1G–LUAD (DFS)

Open the LUAD breakdown →