MT1G

Across TCGA pan-cancer cohorts, MT1G mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MT1G’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MT1G mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MT1G is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where MT1G tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT1G mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−3.246	<.001	12	view →
PDAC	Female	All	−1.886	<.001	7	view →
LSCC	Male	III,IV	+1.053	<.001	7	view →
LUAD	All	All	+0.447	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MT1G–CCRCC

Open the CCRCC breakdown →