Across TCGA patient cohorts, MT1A protein abundance is significantly associated with the RNA expression of many other genes, with 2,920 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MT1A-associated genes across cancer lineages are MT1G, NIPAL2, and CLINT1. Each is linked with MT1A in more than 2 cancer types. Because this analysis shows association rather than direction, both MT1A-to-partner and partner-to-MT1A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1A→partner) and Y-score (partner→MT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MT1G →	+2.609	+1.334	<.001	.004	3	3
LSCC	NIPAL2 →	-0.459	-0.686	.007	.002	3	2
LUAD	CLINT1 →	-0.452	-0.587	.001	.008	3	2
LUAD	TMEM159 →	-0.913	-0.701	<.001	<.001	3	2
LSCC	APC →	-0.354	-0.571	<.001	.003	3	2
PDAC	AOX1 →	+1.081	+0.646	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,920 associations by consensus.

Exploration

MT1A survival (RNA) · tumor vs normal (RNA) · all MT1A data types