Across TCGA patient cohorts, MT1A mutation is significantly associated with the RNA expression of many other genes, with 271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT1A-associated genes across cancer lineages are GAGE2E, C17orf98, and MIR7976. Each is linked with MT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1A-to-partner and partner-to-MT1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1A→partner) and Y-score (partner→MT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAGE2E →	+0.217	+5.474	<.001	.005	3	2
UCEC	C17orf98 →	+0.573	+3.450	<.001	.004	3	1
UCEC	MIR7976 →	+0.387	+2.646	.005	.009	3	1
UCEC	FBXL18 →	+0.617	+3.364	.004	.005	3	1
UCEC	ZC3H18 →	+0.548	+3.354	.002	.005	3	1
UCEC	RNF166 →	+0.593	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 271 associations by consensus.

Exploration

MT1A survival (RNA) · tumor vs normal (RNA) · all MT1A data types