Across TCGA patient cohorts, MT1A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT1A-associated genes across cancer lineages are EGFR_pY1068, Notch1, and Caspase-8. Each is linked with MT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1A-to-partner and partner-to-MT1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1A→partner) and Y-score (partner→MT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.313	-3.169	.023	.020	3	1
UCEC	Notch1 →	+0.211	+3.169	.006	.020	3	1
UCEC	Caspase-8 →	-0.284	-2.973	.039	.035	3	1
UCEC	4E-BP1 →	+0.345	+2.837	.020	.035	3	1
UCEC	14-3-3_beta →	-0.126	-3.156	.022	.020	2	1
UCEC	PCNA →	+0.272	+3.169	.021	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

MT1A survival (RNA) · tumor vs normal (RNA) · all MT1A data types