Across TCGA pan-cancer cohorts, MT-TV RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MT-TV data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MT-TV RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MT-TV expression acts as an unfavorable survival marker, although some lineages such as ACC and KICH show a favorable association.

KIRC, LIHC, and OV are the cancer types where MT-TV RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	III,IV	0.556	0.717	<.001	82	view →
LIHC	DFS	Median	II,III,IV	0.341	0.495	.004	48	view →
OV	OS	Tertile	All	0.783	0.906	.005	46	view →
ACC	OS	Median	IV	0.842	0.244	.001	27	view →
UVM	DFS	Quartile	II,III,IV	0.491	0.871	.007	26	view →
UCEC	OS	Quartile	IV	0.231	0.722	.016	24	view →
LUAD	OS	Quartile	II,III,IV	0.436	0.701	.007	19	view →
SARC	DFS	Tertile	All	0.223	0.398	.002	19	view →
THCA	OS	Quartile	IV	0.566	0.897	.004	18	view →
MESO	DFS	Quartile	All	0.237	0.389	.012	13	view →
SKCM	OS	Median	II,III,IV	0.796	0.881	.004	12	view →
PRAD	OS	Quartile	All	0.979	0.999	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

Exploration

Same gene, other analysis: MT-TV tumor-vs-normal RNA expression · all MT-TV data types