Across TCGA pan-cancer cohorts, MT-TC RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MT-TC data layer.
The strongest signal is observed in uterine carcinosarcoma (UCS), where higher MT-TC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MT-TC expression acts as an unfavorable survival marker, although some lineages such as ACC and KIRC show a favorable association.
UCS, ACC, and KIRC are the cancer types where MT-TC RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.