Across TCGA pan-cancer cohorts, MT-ND4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MT-ND4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MT-ND4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MT-ND4 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where MT-ND4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT-ND4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−1.239	<.001	12	view →
COAD	Male	II,III,IV	−0.344	<.001	9	view →
HNSC	Male	II,III,IV	−0.617	<.001	8	view →
PDAC	All	All	−1.500	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MT-ND4 RNA expression & survival · all MT-ND4 data types