Across TCGA cell cohorts, MT-ND4 mutation is significantly associated with the RNA expression of many other genes, with 402 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MT-ND4-associated genes across cancer lineages are ERVW-1, ALG14, and OR9A2. Each is linked with MT-ND4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MT-ND4-to-partner and partner-to-MT-ND4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-ND4→partner) and Y-score (partner→MT-ND4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERVW-1 →	+0.423	+3.510	<.001	<.001	3	4
BREAST	ALG14 →	+0.740	+2.372	.004	.009	3	3
LIVER	OR9A2 →	+0.023	+3.977	<.001	.006	3	2
LARGE_INTESTINE	VSX2 →	+0.013	+2.672	.003	.004	3	2
SKIN	KCNJ18 →	+0.022	+2.657	.005	.007	3	2
BLOOD_Lymphoma	AWAT2 →	+0.017	+3.927	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 402 associations by consensus.

Exploration

MT-ND4 survival (RNA) · tumor vs normal (RNA) · all MT-ND4 data types