Across TCGA pan-cancer cohorts, MT-CO3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MT-CO3 data layer compared with 7 for mass-spec protein.
The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MT-CO3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MT-CO3 expression acts as an unfavorable survival marker, although some lineages such as PAAD and KICH show a favorable association.
SKCM, PAAD, and KICH are the cancer types where MT-CO3 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.