Across TCGA pan-cancer cohorts, MT-CO2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MT-CO2 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MT-CO2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MT-CO2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where MT-CO2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.866	0.602	<.001	48	view →
GBM	DFS	Median	All	0.835	0.609	<.001	15	view →
PDAC	DFS	Quartile	III,IV	0.269	0.589	.019	2	view →
HNSC	DFS	Median	III,IV	0.889	0.722	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MT-CO2 tumor-vs-normal RNA expression · all MT-CO2 data types