MSX2

Across TCGA patient cohorts, MSX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,154 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MSX2-associated proteins across cancer lineages are MSX2_S91, CEMIP, and CTHRC1. Each is linked with MSX2 in more than 7 cancer types. Because this analysis shows association rather than direction, both MSX2-to-partner and partner-to-MSX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSX2 versus MSX2_S91 in BRCA, with a Pearson correlation of 0.85.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX2→partner) and Y-score (partner→MSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MSX2_S91 →	+1.463	+2.315	<.001	<.001	3	8
UCEC	CEMIP →	+0.833	+2.061	<.001	<.001	3	5
OV	CTHRC1 →	+1.308	+0.949	<.001	<.001	3	5
OV	FBLN1 →	+0.948	+1.062	<.001	<.001	3	5
UCEC	UNC5B →	+0.616	+2.276	.002	.006	2	5
OV	PTK7 →	+0.465	+0.833	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,154 associations by consensus.

MSX2 vs MSX2_S91 — BRCA

Explore this scatter interactively →