MSX2

Across TCGA patient cohorts, MSX2 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSX2-associated genes across cancer lineages are Erythrocytes, Preadipocytes, and Adipocytes. Each is linked with MSX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSX2-to-partner and partner-to-MSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erythrocytes grouped by MSX2-low versus MSX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX2→partner) and Y-score (partner→MSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Erythrocytes →	+0.040	+2.656	<.001	.005	3	2
COAD	Preadipocytes →	+0.061	+4.754	<.001	.003	3	1
UCEC	Adipocytes →	+0.019	+3.092	.011	.001	3	1
UCEC	Endothelial cells →	-0.039	-2.279	.014	.006	3	1
UCEC	mv Endothelial cells →	-0.022	-3.459	.020	.005	3	1
UCEC	Th2 cells →	+0.183	+2.321	.013	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Erythrocytes by MSX2 expression — UCEC

Explore this box plot interactively →