MSX2

Across TCGA cell cohorts, MSX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,957 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MSX2-associated GO terms across cancer lineages are Endosomal vesicle fusion, Positive regulation of fat cell differentiation, and Surfactant homeostasis. Each is linked with MSX2 in more than 8 cancer types. Because this analysis shows association rather than direction, both MSX2-to-partner and partner-to-MSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal vesicle fusion grouped by MSX2-low versus MSX2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX2→partner) and Y-score (partner→MSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Endosomal vesicle fusion →	+0.102	+2.674	<.001	<.001	3	9
STOMACH	Positive regulation of fat cell differentiation →	+0.077	+2.149	<.001	<.001	3	6
URINARY_TRACT	Surfactant homeostasis →	+0.274	+2.508	<.001	<.001	3	6
URINARY_TRACT	Phospholipid biosynthetic process →	+0.043	+1.822	<.001	.005	3	6
OESOPHAGUS	Substrate-independent telencephalic tangential migration →	-1.004	-1.888	.003	<.001	3	6
OESOPHAGUS	Interneuron migration from the subpallium to the cortex →	-1.004	-1.888	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,957 associations by consensus.

Endosomal vesicle fusion by MSX2 expression — BREAST

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